TLS Online TPP Program

#Question id: 5648


Use the following information to answer the question. In order to test how sea urchin sperm bind to eggs, scientists isolated the egg receptor protein that binds to the sperm acrosomal protein called bindin. Plastic beads were coated with egg receptor for bindin (ERB1) from eggs of the sea urchin Strongylocentrotus purpuratus, and then the beads mixed with sperm from S. purpuratus or from the related species, S. franciscanus. The researchers counted how many sperm were bound to each bead. The results are shown in the graph below. Treatments:

A: S. purpuratus sperm mixed with S. purpuratus ERB1 beads

B: S. purpuratus sperm mixed with beads containing no ERB1 protein

C: S. franciscanus sperm mixed with S. purpuratus ERB1 beads

D: S. franciscanus sperm mixed with beads containing no ERB1 protein

 What is a broader implication from the observations of the experiment?

#Unit 5. Developmental Biology
  1. In sea urchins, fertilization of eggs by sperm is dependent upon species-specific protein interactions.

  2. Only some species of sea urchins use receptor proteins on their eggs to bind sperm.

  3. Protein-coated plastic beads should not be used to test sperm binding to eggs.

  4. S. franciscanus is probably not a sea urchin, but must be some other type of organism.

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TLS Online TPP Program

#Question id: 19111

#Unit 8. Inheritance Biology

If the frequency of PKU among newborns is approximately 1/10,000 (when the parents are unrelated). What is the risk of a child with PKU if the parents are uncle and niece?

TLS Online TPP Program

#Question id: 19112

#Unit 8. Inheritance Biology

the frequency of PKU among newborns is approximately 1/10,000 (when the parents are unrelated). What is the risk of a child with PKU if the parents are second cousins?

TLS Online TPP Program

#Question id: 19113

#Unit 8. Inheritance Biology

P, Q, and R are three different inbred, true-breeding strains of mice. A hybrid between P and Q is mated to R, and a hybrid between Q and R is mated to P. A male from the first mating is mated to a female from the second mating. What is the inbreeding coefficient of their progeny?

TLS Online TPP Program

#Question id: 19114

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal recessive disease whose chromosomal location has not been firmly established. You are focused on two SSR markers that may be linked to each other and to the disease. Here are two families in which some individuals are affected:
                                       
Calculate LOD scores for linkage at θ= 0.02 between the disease and SSR42 in Family 1.

TLS Online TPP Program

#Question id: 19115

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal recessive disease whose chromosomal location has not been firmly established. You are focused on two SSR markers that may be linked to each other and to the disease. Here are two families in which some individuals are affected:
                
Calculate LOD scores for linkage at θ= 0.02 between the disease and SSR43 in Family 1.

TLS Online TPP Program

#Question id: 19116

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal recessive disease whose chromosomal location has not been firmly established. You are focused on two SSR markers that may be linked to each other and to the disease. Here are two families in which some individuals are affected:
                             
Calculate LOD scores for linkage at θ= 0.02 between the disease and SSR42 in Family 2.