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TLS Online TPP Program

#Question id: 7143

The development of drugs to block the activity of vascular endothelial growth factor (VEGF) has been applied to the control of the growth of cancers. What is the rationale for such a strategy?

#Unit 5. Developmental Biology
  1. Tumor cells produce VEGF to stimulate angiogenesis in their vicinity, and tumors cannot continue to grow without this supply of blood.
  2. Blocking VEGF prevents vasculogenesis in the embryo, and if done properly prevents cancer later in life.
  3. VEGF causes blood vessels to grow toward cancers, which kills the cancer due to too much blood.
  4. VEGF is a key controller of the adoption of tumor phenotypes by cells, so blocking it will help control cancer.
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TLS Online TPP Program

#Question id: 27961

#Unit 1. Molecules and their Interaction Relevant to Biology

Conversion of Glucose 6-phosphate →  Ribulose 5-phosphate in oxidative phase involves

(a) 2NADP

(b) Removal of 1 CO2

(c) Uses G6PD as enzyme 

(d) No 2NADP is required
TLS Online TPP Program

#Question id: 27962

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of following is true regarding the Transketolase and Transaldolase
a. Transketolase catalyzes the transfer of a two-carbon fragment from a ketose donor to an aldose acceptor with TPP
b. Transketolase catalyzes the transfer of a three-carbon fragment from a ketose donor to an aldose acceptor with TPP
c. Transaldolase catalyses the transfer of a two-carbon fragment
d. Transaldolase catalyses the transfer of a three-carbon fragment
TLS Online TPP Program

#Question id: 27963

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following is completely true about the α-ketoglutarate dehydrogenase complex
TLS Online TPP Program

#Question id: 27964

#Unit 1. Molecules and their Interaction Relevant to Biology

Enzymes their location and cofactor along with the inhibitors is given 
a. Citrate synthase Located in Matrix space uses CoA as cofactor and can be inhibited by Monofluoroacetyl-CoA
b. Aconitase Located in Inner membrane uses Fe2+ as cofactor and can be inhibited by Fluoro acétate
c. Isocitrate dehydrogenase Located Matrix space in uses NAD, NADP Mg2+. Mn2+ as cofactor and can be inhibited by ATP
d. Succinate dehydrogenase Located in Inner membrane uses FAD as cofactor and can be inhibited by Malonate, Oxaloacetate

Which of the following is correct
TLS Online TPP Program

#Question id: 27965

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following provide moonlighting for  both uracil DNA glycosylase, effecting the repair of damaged DNA, and as a regulator of histone H2B transcription 
TLS Online TPP Program

#Question id: 27966

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following acts in the nucleus to regulate the transcription of genes that respond to thyroid hormone.