TLS Online TPP Program

#Question id: 7143


The development of drugs to block the activity of vascular endothelial growth factor (VEGF) has been applied to the control of the growth of cancers. What is the rationale for such a strategy?

#Unit 5. Developmental Biology
  1. Tumor cells produce VEGF to stimulate angiogenesis in their vicinity, and tumors cannot continue to grow without this supply of blood.
  2. Blocking VEGF prevents vasculogenesis in the embryo, and if done properly prevents cancer later in life.
  3. VEGF causes blood vessels to grow toward cancers, which kills the cancer due to too much blood.
  4. VEGF is a key controller of the adoption of tumor phenotypes by cells, so blocking it will help control cancer.