TLS Online TPP Program

#Question id: 724


In 1988, Richardson and Richardson observed that certain amino acid residues are statically favored as the amino-terminal caps for the alpha helices in 45 globular proteins. Which of the following statement stand correct with stability of helix?

A. The introduction of a negatively charged side chain at the N-cap, which can neutralize the partial dipole created by the unpaired amide protons, has been shown to increase stability

B. In particular, Gly is often observed at the both C-cap position and N-cap positions

C. In particular, Gly is often observed at the C-cap position only

D. In particular, Gly is often observed at the C-cap position, Asn at the N-cap position, Pro at the Ncap+1 and Asp and Glu at N2 and N3

#Unit 1. Molecules and their Interaction Relevant to Biology
  1. D only

  2. B Only

  3. C Only

  4. A, B & D