Practice Questions

TLS Online TPP Program

#Question id: 12908

Which statement is incorrect about CRISPR?

#Unit 13. Methods in Biology

It was first identified as an adaptive immunity pathway in prokaryotes providing resistance to bacteriophage and analogous to the RNA interference process found in eukaryotes.
It does not utilize double-stranded sequence-specific breaks and does not repair using HDR via homologous recombination.
The system consists of two parts, a short synthetic guide RNA ( gRNA) and a nonspecific double-stranded endonuclease termed Cas9.
It is also possible to program Cas9 with multiple guide RNAs to allow multiplex site-specific editing for designing large deletions, inversions and translocations.

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TLS Online TPP Program

#Question id: 33530

#Unit 2. Cellular Organization

One approach to determine the number of essential genes

A. Mutational Analysis

B. Sequence Alignments

C. Complementation

D. Mass Spectroscopy

TLS Online TPP Program

#Question id: 33531

#Unit 2. Cellular Organization

The data obtained during DNA microarray analysis showing wildtype vs. mutant expression of genes under different conditions, represented as

TLS Online TPP Program

#Question id: 33691

#Unit 2. Cellular Organization

TLS Online TPP Program

#Question id: 33692

#Unit 2. Cellular Organization

Gene families with the highest number of pseudogenes are

A. Olfactory Receptor (OR)

B. Immunoglobulin (Ig)

C. Zinc Finger Protein (ZNF)

D. Globin gene family

TLS Online TPP Program

#Question id: 33693

#Unit 2. Cellular Organization

Satellite DNA arise due to

TLS Online TPP Program

#Question id: 33694

#Unit 2. Cellular Organization

Find true & false statements

A. Gene clusters mispairing between nonallelic loci can cause unequal crossing over.

B. Unequal crossing over produces a deletion in one recombinant chromosome and a corresponding duplication in the other.

C. Different thalassemias are caused by various duplication that eliminate a- or b-globin genes.