T-Cell Development

1.Commitment

2.antigen receptor gene rearrangements

3.The selection and expansion of cells (β-selection

TLS Online TPP Program

#Id: 8156

#Section 3: Genetics, Cellular and Molecular Biology

Two different kinds of sorting signals:

Membrane cargo proteins carry cytoplasmic sorting signals

Soluble cargo proteins carry luminal sorting signals

TLS Online TPP Program

#Id: 8852

#Section 3: Genetics, Cellular and Molecular Biology

Geminin contains a destruction box at its N-terminus that is recognized by APC/Ccdh1, causing it to be ubiquitinylated in late anaphase and degraded by proteasomes.

TLS Online TPP Program

#Id: 3772

#Section 2: General Biology

Matter is anything that takes up space and has mass.

TLS Online TPP Program

#Id: 8116

#Section 2: General Biology

Fingolimod—a Sphingosine-1-P Mimic Is an Oral Drug for Multiple Sclerosis

TLS Online TPP Program

#Id: 7944

#Section 3: Genetics, Cellular and Molecular Biology

Membrane and soluble secretory proteins synthesized on the rough ER undergo four principal modifications before they reach their final destinations: 

(1) Glycosylation in the ER and Golgi complex

(2) Formation of disulfide bonds in the ER

(3) Proper folding of polypeptide chains and assembly of multisubunit proteins in the ER

(4) Specific proteolytic cleavages in the ER, Golgi complex, and secretory vesicles