One individual, however, expresses only a small number of these molecules—up to six different class I molecules and 12 or more different class II molecules.

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Phosphorylation on multiple sites by G1 CDKs blocks Rb from associating with E2F and promotes its export out of the nucleus.

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Rb protein regulation by G1 CDKs in mammalian cells is analogous to Whi5 regulation by Cln3-CDK in yeast.

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One of the important substrates of the G1/S phase cyclin-CDK complexes is Cdh1.

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During exit from mitosis and G1, 

Cdh1 is de-phosphorylated and APC/Ccdh1 is active.

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During S phase and mitosis, 

Cdh1 is phosphorylated, Cdh1 dissociates from APC/C, and APC/C becomes inactive.