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They are pAPCs
Have surface marker  CD19
Antibodies at surface of b cell – IgM, IgD
Cause humoral immunity or antibodies mediated immunity

#XL - Q Biochemistry #B-cell #Part B Pointers
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TLS Online TPP Program

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#XL - T Zoology

Feedback regulation by MAP Kinase
Active MAP kinase phosphorylates Raf on multiple sites, reducing its association with Ras.

TLS Online TPP Program

#Id: 9657

#XL - T Zoology

Negative feedback regulation by MAP Kinase
activated MAP kinase triggers an increase in the expression of dual-specificity phosphatases (DUSPs), particularly DUSP6.

TLS Online TPP Program

#Id: 9658

#XL - T Zoology

Hormonal stimulation of GPCR leads to the activation of PLC (IP3/DAG pathway).

TLS Online TPP Program

#Id: 9659

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GPCRs specifically activate the β isoform of PLC (PLCβ)

TLS Online TPP Program

#Id: 9660

#XL - T Zoology

Many RTKs and cytokine receptors specifically activate the γ isoform (PLCγ), which contains an SH2 domain.

TLS Online TPP Program

#Id: 9661

#XL - T Zoology

Activated RTKs and cytokine receptors promote PLCγ activity in two ways: 
By localizing PLCγ to the membrane
By phosphorylating PLCγ

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