An individual carrying the allele can pass copies of it to his or her own children. This is the allele’s direct fitness. The allele can also pass extra copies of itself to the next generation as the result of the increased fitness of relatives that benefit from the altruistic individual’s actions. This is the allele’s indirect fitness. 

TLS Online TPP Program

#Id: 10052

#XL - T Zoology

Second cleavage of Notch occurs within membrane-spanning region & catalyzed by γ-secretase

TLS Online TPP Program

#Id: 10053

#XL - T Zoology

γ-secretase complex contains 

Presenilin 1 (actual protease), aph-1, pen-2, & nicastrin

TLS Online TPP Program

#Id: 10054

#XL - T Zoology

Cleavage by the γ-secretase complex releases the Notch cytosolic segment, which translocates to the nucleus, interacts with a single DNA-binding transcription factor, CSL.

TLS Online TPP Program

#Id: 10055

#XL - T Zoology

Growth factors and EGFs are synthesized as TM proteins, regulated cleavage of the precursor by members of the ADAM protease releases the active molecule into the extracellular space.

TLS Online TPP Program

#Id: 10056

#XL - T Zoology

Cell-adhesion molecules (CAMs) mediate direct cell-cell adhesions.

TLS Online TPP Program

#Id: 10057

#XL - T Zoology

Adhesion receptors mediate cell-matrix adhesions