For selective export of certain membrane proteins from the ER contain a di-acidic sorting signal (Asp-X-Glu, or DXE), which binds to the Sec24 subunit of the COPII

TLS Online TPP Program

#Id: 8162

#XL - Q Biochemistry

For selective export of certain membrane proteins from the ER contain a di-acidic sorting signal (Asp-X-Glu, or DXE), which binds to the Sec24 subunit of the COPII

TLS Online TPP Program

#Id: 10343

#XL - Q Biochemistry

The heavy chain is then expressed on the cell surface in combination with the surrogate light chain, which is made up of VpreB and λ5. 

TLS Online TPP Program

#Id: 10344

#XL - Q Biochemistry

B- cell maturation

TLS Online TPP Program

#Id: 10345

#XL - Q Biochemistry

T1 and T2 Transitional B Cells

TLS Online TPP Program

#Id: 10346

#XL - Q Biochemistry

T1 cells are mIgMhi, mIgD -/lo, CD21-, CD23-, CD24+, and CD93+. 

T2 cells differ from T1 cells in having higher levels of mIgD and in expressing CD21 and CD23. 

TLS Online TPP Program

#Id: 10347

#XL - Q Biochemistry

Transitional B cells bound for a follicular fate undergo positive and negative selection in the spleen.

TLS Online TPP Program

#Id: 10348

#XL - Q Biochemistry

BAFF-R expression is first detected in T1 B cells and increases steadily there after.

Signaling through the BAFF/BAFF-R axis promotes survival of transitional B cells by inducing the synthesis of anti-apoptotic factors such as Bcl-2, Bcl-xl, and Mcl-1