KDEL receptor, located mainly in the cis-Golgi network and in both COPII and COPI vesicles, binds proteins bearing the KDEL sorting signal and returns them to the ER

TLS Online TPP Program

#Id: 8159

#XL - Q Biochemistry

KDEL receptor, located mainly in the cis-Golgi network and in both COPII and COPI vesicles, binds proteins bearing the KDEL sorting signal and returns them to the ER

TLS Online TPP Program

#Id: 7878

#XL - Q Biochemistry

Crista junction

The connection between the inner boundary membrane and a crista

TLS Online TPP Program

#Id: 7879

#XL - Q Biochemistry

The curvature of the crista junctions is due to a protein complex called MICOS (mitochondrial contact site and cristae organizing system).

TLS Online TPP Program

#Id: 7880

#XL - Q Biochemistry

MICOS has an integral membrane protein subunit that homo-oligomerizes and bends the inner membrane to produce high curvature.

TLS Online TPP Program

#Id: 7881

#XL - Q Biochemistry

MICOS mediates close juxtaposition of the outer membrane and inner membrane by binding to outer membrane–associated proteins

TLS Online TPP Program

#Id: 7882

#XL - Q Biochemistry

The binding partners for MICOS in the outer membrane are Tom and SAM protein complexes, (involved in import of proteins into the mitochondria). 

TLS Online TPP Program

#Id: 7883

#XL - Q Biochemistry

MICOS function as a diffusion barrier to prevent mixing of the distinct proteins and lipids in the boundary membrane and crista membranes.