KDEL receptor, located mainly in the cis-Golgi network and in both COPII and COPI vesicles, binds proteins bearing the KDEL sorting signal and returns them to the ER

TLS Online TPP Program

#Id: 8159

#XL - Q Biochemistry

KDEL receptor, located mainly in the cis-Golgi network and in both COPII and COPI vesicles, binds proteins bearing the KDEL sorting signal and returns them to the ER

TLS Online TPP Program

#Id: 9350

#XL - T Zoology

RI and RII receptors are homodimeric proteins with serine/threonine kinases in their cytosolic domains. 

(RI and RII sufficient to serve as a functional hetero-tetrameric TGF-β receptor)

TLS Online TPP Program

#Id: 9351

#XL - T Zoology

RII exhibits constitutive kinase activity; means it is active even when not bound to TGF-β.

TLS Online TPP Program

#Id: 9352

#XL - T Zoology

RIII, also called β-glycan, is a cell-surface proteoglycan.

TLS Online TPP Program

#Id: 9353

#XL - T Zoology

The function of RIII for TGF-β receptors is similar to that of the α subunit of the IL-2 receptor 

(means facilitating TGF-β binding to the RII and RI)

   

         

TLS Online TPP Program

#Id: 9355

#XL - T Zoology

Most cells lack RIII, TGF-β binds directly to the RII

dimer, but Active RII kinase activity is not sufficient to generate an intracellular signal

TLS Online TPP Program

#Id: 9356

#XL - T Zoology

RI will not bind to RII unless RII is bound to TGF-β.