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#XL - Q Biochemistry

Soluble ER-resident proteins contain C-terminal KDEL sorting signal that allows them to be retrieved. 

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These cells wall off the organism inside a granuloma called a tubercle. The localized concentrations of lysosomal enzymes in these granulomas can cause extensive tissue necrosis.

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Dollo’s law:  A biological generalization positing that complex characters, once lost in evolution, are extremely unlikely to reappear and thus the loss of complex characters is virtually always irreversible.

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Binding of cAMP by an R subunit of PKA occurs in a cooperative fashion; i.e., binding of the first cAMP molecule to CNB-B lowers the Kd for binding of the second cAMP to CNB-A.

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