Suppressor of cAMP/PKA signalling Pathway- cAMP PDE (hydrolyze cAMP to 5′-AMP)

TLS Online TPP Program

#Id: 9958

#XL - T Zoology

Structure of Wnt proteins 

22 cysteine residues, which form disulfide bridges that maintain a globular secondary structure.

TLS Online TPP Program

#Id: 9959

#XL - T Zoology

Wnt = wingless + integrated

TLS Online TPP Program

#Id: 9960

#XL - T Zoology

Wnt proteins are modified by linkage of a monounsaturated fatty acid, palmitoleic acid, to a serine in the middle of the protein.

TLS Online TPP Program

#Id: 9961

#XL - T Zoology

Lipid modifications of Wnt are catalyzed by the 

O-acetyltransferase Porcupine.

TLS Online TPP Program

#Id: 9962

#XL - T Zoology

Principal signaling receptor is Frizzled (Fz), contains 

7 TM α helices.

TLS Online TPP Program

#Id: 9963

#XL - T Zoology

The palmitoleate attached to the Wnt protein binds to a specific site on the Fz extracellular domain and stabilizes the Wnt-Fz complex.