The reaction catalyzed by citrate synthase is essentially a Claisen condensation, involving a thioester (acetyl-CoA) and a ketone (oxaloacetate)

TLS Online TPP Program

#Id: 9976

#XL - T Zoology

Formation of the Wnt/Fz/LRP complex at the cell

surface causes the adaptor protein Dishevelled, to bind to Fz and Axin to bind to LRP, resulting destabilization and inactivation of the destruction complex

TLS Online TPP Program

#Id: 9977

#XL - T Zoology

Unphosphorylated β-catenin translocates to the nucleus.

TLS Online TPP Program

#Id: 9978

#XL - T Zoology

β-catenin binds to TCF to displace the Gro repressor and recruits co-activator proteins Pygo, LGS, to activate target gene expression.

TLS Online TPP Program

#Id: 9979

#XL - T Zoology

Active Wnt signaling leads to the secretion of Notum.

TLS Online TPP Program

#Id: 9980

#XL - T Zoology

Notum, a hydrolase that associates with glypican and then cleaves off Wnt’s attached lipids in a process of deacylation or delipidation.

TLS Online TPP Program

#Id: 9981

#XL - T Zoology

Delipidation process reduces Wnt signaling, creates a negative feedback mechanism for preventing excessive Wnt signaling.