Inbreeding

Preferential mating between related individuals. Inbreeding is more likely to take place in nature when population size becomes very small, and the number of mates is limited.

TLS Online TPP Program

#Id: 9677

#XL - T Zoology

Activated PKB directly phosphorylates and inactivates a protein Bad

TLS Online TPP Program

#Id: 9678

#XL - T Zoology

Activated PKB also promotes survival of many cultured cells by phosphorylating the Forkhead transcription factor FOXO3a on multiple serine and threonine residues.

TLS Online TPP Program

#Id: 9679

#XL - T Zoology

The cytosolic phosphoserine binding protein 14-3-3 then binds to phosphorylated FOXO3a and sequesters it in the cytosol.

TLS Online TPP Program

#Id: 9680

#XL - T Zoology

A FOXO3a mutant in which the three serine residues that are targets for PKB are mutated to alanines is constitutively active

TLS Online TPP Program

#Id: 9681

#XL - T Zoology

PI-3 kinase signaling pathway is terminated by

PTEN phosphatase, which hydrolyzes the 3-phosphate

in PI 3-phosphates.

TLS Online TPP Program

#Id: 9682

#XL - T Zoology

PTEN can remove phosphate groups attached to serine,

threonine, and tyrosine residues in proteins, its ability to

remove the 3-phosphate from PI(3,4,5)P3 is its major function in cells.