TLS Online TPP Program

#Id: 7898

#XL - Q Biochemistry

TLS Online TPP Program

#Id: 9651

#XL - T Zoology

Phosphorylation by MEK at Y-185 and T-183 in activation loop of MAP kinase leads to a marked conformational change & promotes MAP kinase activation and dimerization.

TLS Online TPP Program

#Id: 9652

#XL - T Zoology

TLS Online TPP Program

#Id: 9653

#XL - T Zoology

Activated dimeric MAP kinase induces transcription of the c-fos gene by directly activating TCF, and indirectly activating SRF.

TLS Online TPP Program

#Id: 9654

#XL - T Zoology

Feedback regulation by MAP Kinase

activated MAP kinase phosphorylates the HER1 on a threonine residue near the juxtamembrane domain. 

TLS Online TPP Program

#Id: 9655

#XL - T Zoology

Feedback regulation by MAP Kinase

Phosphorylation of threonine residue in HER1 decreases the ability of the receptor kinase to become fully active.

TLS Online TPP Program

#Id: 9656

#XL - T Zoology

Feedback regulation by MAP Kinase

Active MAP kinase phosphorylates Raf on multiple sites, reducing its association with Ras.