Fingolimod—a Sphingosine-1-P Mimic Is an Oral Drug for Multiple Sclerosis

TLS Online TPP Program

#Id: 8116

#XL - T Zoology

Fingolimod—a Sphingosine-1-P Mimic Is an Oral Drug for Multiple Sclerosis

TLS Online TPP Program

#Id: 9325

#XL - T Zoology

Each opsin molecule has multiple principal serine and threonine phosphorylation sites on its cytosol-facing C-terminal segment.

TLS Online TPP Program

#Id: 9326

#XL - T Zoology

TLS Online TPP Program

#Id: 9328

#XL - T Zoology

Arrestin binds tightly to rhodopsin only when rhodopsin kinase has phosphorylated a sufficient number of C-terminal serines and threonines.

TLS Online TPP Program

#Id: 9329

#XL - T Zoology

The entire process of rhodopsin phosphorylation and its inactivation by arrestin is fast completed within 50ms. 

TLS Online TPP Program

#Id: 9330

#XL - T Zoology

Phosphorylated rhodopsin is restored to its light-sensitive state (R) during dark adaptation by a specific rhodopsin phosphatase

TLS Online TPP Program

#Id: 9331

#XL - T Zoology

In the dark, most transducin is localized to the outer segment, while most arrestin is found in other parts of the cell; in this condition, vision is most sensitive to very low light levels.