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TLS Online TPP Program

#Id: 8154

Sar1 GTPase drives the pinching off of COPII vesicles
ARF GTPase drives the pinching off of COPIvesicles
Dynamin GTPase drives the pinching off of clathrin-coated vesicles

#XL - Q Biochemistry #Golgi Apparatus #Part B Pointers
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TLS Online TPP Program

#Id: 8154

#XL - Q Biochemistry

Sar1 GTPase drives the pinching off of COPII vesicles
ARF GTPase drives the pinching off of COPIvesicles
Dynamin GTPase drives the pinching off of clathrin-coated vesicles
TLS Online TPP Program

#Id: 10037

#XL - T Zoology

IL-1β receptors contain a globular TIR domain; binding of IL-1β to IL-1 receptors triggers dimerization
TLS Online TPP Program

#Id: 10038

#XL - T Zoology

After dimerization MyD88 proteins bind to the IL-1R through the TIRs, and facilitates the binding of many copies of the kinases IRAK4 and IRAK1 or IRAK2
TLS Online TPP Program

#Id: 10039

#XL - T Zoology

Activated IRAK1/2, binds TRAF6, an E3 ubiquitin ligase, to the signalsome, and promotes the formation of an extended 2-D lattice formed by TRAF6-TRAF6 interactions.
TLS Online TPP Program

#Id: 10040

#XL - T Zoology

TRAF6 catalyzes synthesis of long K-63-linked polyubiquitin chains that are covalently linked to TRAF6 itself.
TLS Online TPP Program

#Id: 10041

#XL - T Zoology

Rather than degradation, poly-K63 ubiquitin chains act as scaffolds that bind proteins that have a poly-K63 ubiquitin-binding domain
TLS Online TPP Program

#Id: 10042

#XL - T Zoology

Poly-K63 ubiquitin-binding domain containing proteins:
Protein kinase TAK1
NEMO subunit of the I-κB kinase