CFTR protein contains

a di-acidic sorting signal that binds to the Sec24 subunit

of the COPII vesicle coat and is necessary for transport of

the CFTR protein out of the ER.

TLS Online TPP Program

#Id: 8166

#XL - Q Biochemistry

CFTR protein contains

a di-acidic sorting signal that binds to the Sec24 subunit

of the COPII vesicle coat and is necessary for transport of

the CFTR protein out of the ER.

TLS Online TPP Program

#Id: 8559

#XL - Q Biochemistry

Dixon plot for competitive inhibition

TLS Online TPP Program

#Id: 8560

#XL - Q Biochemistry

TLS Online TPP Program

#Id: 8561

#XL - Q Biochemistry

Uncompetitive inhibitors bind only to the enzyme-substrate complex and not to the free enzyme. 

TLS Online TPP Program

#Id: 8562

#XL - Q Biochemistry

In neither case does the inhibitor compete with the substrate for the same binding site, so the inhibition cannot be overcome by increasing the substrate concentration.

TLS Online TPP Program

#Id: 8563

#XL - Q Biochemistry

Substrate-binding could cause a conformational change to take place in the enzyme and reveal an inhibitor binding site, or the inhibitor could bind directly to the enzyme-bound substrate. 

TLS Online TPP Program

#Id: 8564

#XL - Q Biochemistry