Population distributions have five important characteristics

Geographic range

Abundance

Density

Dispersion

Dispersal

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Wee1 kinase Inhibits CDKs in all organisms

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Cdc25 phosphatase Activates CDKs in fission yeast

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INK4s

bind to CDK4 and CDK6 monomers, blocking their interaction with cyclin D

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A second class of CKIs found in metazoan cells is the Cip/Kip family of CKIs, consists of three proteins—p21CIP, p27KIP1, and p57KIP2. 

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The Cip/Kip family members bind to cyclin-bound CDKs and block the activity of cyclin D-, E-, A-, and B-containing complexes.

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Cyclins are degraded through the action of two different E3-ligases:

1. SCF (Skp1, Cullin, and F-box proteins) 

2. APC/C or cyclosome