The Eisenthal and Cornish-Bowden plot at constant v0 and [S0], a plot of V max against Km is linear.

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During S phase and mitosis, 

Cdh1 is phosphorylated, Cdh1 dissociates from APC/C, and APC/C becomes inactive.

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G1/S phase CDKs phosphorylate Cdh1 at the 

G1-S phase transition

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S phase cyclin-CDK accumulates in late G1 , they are immediately inactivated by binding of a CKI called Sic1

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Degradation of Sic1 is induced by its phosphorylation by G1/S phase CDKs.

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Sic1 inhibitor is degraded following its ubiquitinylation by the SCF ubiquitin-protein ligase