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Polygalacturonases (PG) secreted by the fungal hyphae interact with WAK1 on plant cell wall results in the expression of plant defense proteins, including PGIPs Chitinases, glucanases, and phytoalexins to damage the fungal hyphae

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During S phase and mitosis, 
Cdh1 is phosphorylated, Cdh1 dissociates from APC/C, and APC/C becomes inactive.

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G1/S phase CDKs phosphorylate Cdh1 at the 
G1-S phase transition

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S phase cyclin-CDK accumulates in late G1 , they are immediately inactivated by binding of a CKI called Sic1

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Degradation of Sic1 is induced by its phosphorylation by G1/S phase CDKs.

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Sic1 inhibitor is degraded following its ubiquitinylation by the SCF ubiquitin-protein ligase

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