During S phase and mitosis, 

Cdh1 is phosphorylated, Cdh1 dissociates from APC/C, and APC/C becomes inactive.

TLS Online TPP Program

#Id: 8649

#XL - T Zoology

During S phase and mitosis, 

Cdh1 is phosphorylated, Cdh1 dissociates from APC/C, and APC/C becomes inactive.

TLS Online TPP Program

#Id: 8563

#XL - Q Biochemistry

Substrate-binding could cause a conformational change to take place in the enzyme and reveal an inhibitor binding site, or the inhibitor could bind directly to the enzyme-bound substrate. 

TLS Online TPP Program

#Id: 8564

#XL - Q Biochemistry

TLS Online TPP Program

#Id: 8565

#XL - Q Biochemistry

In the simplest possible model, simple linear non-competitive inhibition, the substrate does not affect inhibitor-binding. 

TLS Online TPP Program

#Id: 8566

#XL - Q Biochemistry

Under these conditions, the reactions have an identical dissociation constant Ki , again called the inhibitor constant. 

TLS Online TPP Program

#Id: 8568

#XL - Q Biochemistry

In the presence of a non-competitive inhibitor which will bind equally well to E or to ES- Vmax decreases but not Km 

TLS Online TPP Program

#Id: 8569

#XL - Q Biochemistry

In case of nonidentical dissociation constants, MIXED TYPE INHIBITION TAKES PLACE