Sic1 inhibitor is degraded following its ubiquitinylation by the SCF ubiquitin-protein ligase

TLS Online TPP Program

#Id: 8654

#XL - T Zoology

Sic1 inhibitor is degraded following its ubiquitinylation by the SCF ubiquitin-protein ligase

TLS Online TPP Program

#Id: 9476

#XL - T Zoology

SOCS proteins 

expression is induced by the STAT5 in erythroid progenitor cells, inhibit or permanently terminate signaling over longer periods

TLS Online TPP Program

#Id: 9477

#XL - T Zoology

All SOCS proteins contains:

SH2 domain

SOCS box

TLS Online TPP Program

#Id: 9478

#XL - T Zoology

SOCS box, 

Recruits E3 ubiquitin ligases that polyubiquitinylate the receptor and the JAK kinase & marks the proteins for destruction by a proteasome

TLS Online TPP Program

#Id: 9479

#XL - T Zoology

SOCS-1, binds to the critical phosphotyrosine in the activation loop of an activated JAK2 kinase, inhibiting its catalytic activity

TLS Online TPP Program

#Id: 9481

#XL - T Zoology

TLS Online TPP Program

#Id: 9608

#XL - T Zoology

For most, but not all, RTKs, the weakly active kinase in each subunit is phosphorylate a key tyrosine in the activation loop of the other subunit (trans-phosphorylation)