Listeria is a food-borne bacterial pathogen has on its surface a protein ActA, which mimics an NPF that efficiently activates the Arp2/3 complex.

TLS Online TPP Program

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Homophilic Binding 

A CAM on one cell can directly bind to the same kind of CAM on an adjacent cell

TLS Online TPP Program

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Heterophilic Binding

A CAM on one cell can directly bind to a different class of CAM on an adjacent cell

TLS Online TPP Program

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The formation of many cell-cell adhesions entails two types of molecular interactions:

1.Trans binding interactions 

2. Cis binding interactions

TLS Online TPP Program

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Trans interactions (intercellular or adhesive interactions)

CAMs on one cell bind to CAMs on an adjacent cell. 

TLS Online TPP Program

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In cis interactions (intracellular or lateral interactions)

monomeric CAMs on one cell bind to one or more CAMs in the same cell’s plasma membrane

TLS Online TPP Program

#Id: 10063

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CAMs fall into one of four major families: 

Cadherins

Immunoglobulin (Ig) superfamily

Integrins

Selectins