KDC shows Divergent evolution, in which the genes for an enzyme with one substrate specificity give rise, during evolution, to closely related enzymes with different substrate specificities but the same enzymatic mechanism.

TLS Online TPP Program

#Id: 9466

#XL - T Zoology

Binding resembles the insertion of a two-pronged “plug” the phosphotyrosine and isoleucine side chains

of the peptide into a two-pronged “socket” in the SH2 domain.

TLS Online TPP Program

#Id: 9467

#XL - T Zoology

SH2 domain of STAT binds to a specific phosphotyrosine in the cytosolic domain of an activated receptor

TLS Online TPP Program

#Id: 9468

#XL - T Zoology

Erythropoietin receptor & the receptors for GH, prolactin, G-CSF, activates STAT5 but not STATs 1, 2, 3, or 4. 

TLS Online TPP Program

#Id: 9469

#XL - T Zoology

IL-2 receptor complex activates

STATs 1, 3, and 5 but not STATs 2 or 4

TLS Online TPP Program

#Id: 9470

#XL - T Zoology

Phosphorylated STAT dissociates spontaneously from the receptor, and two phosphorylated STAT proteins form a homodimer.

TLS Online TPP Program

#Id: 9471

#XL - T Zoology

STAT5 becomes activated in erythroid progenitor cells and induces expression of the protein Bcl-xL.