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KDC shows Divergent evolution, in which the genes for an enzyme with one substrate specificity give rise, during evolution, to closely related enzymes with different substrate specificities but the same enzymatic mechanism.

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TLS Online TPP Program

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The predominant hexokinase isozyme of liver is hexokinase IV (glucokinase) and it is GLUT2 dependent

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Hexokinase IV is not inhibited by glucose 6-phosphate, and it can therefore continue to operate 
when the accumulation of glucose 6-phosphate completely inhibits hexokinases I–III. 

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