Guanidinium ion and urea are chaotropic agents which disrupts hydrophobic core of proteins.

TLS Online TPP Program

#Id: 8860

#XL - T Zoology

During S phase

DNA-bound G1 cohesins Convert into cohesive complexes by cohesin acetyl transferases (CoATs)

which acetylate Smc3 subunit & prevents unloading of cohesins by Pds5-Wapl, thereby stabilizing the cohesins on chromosomes.

TLS Online TPP Program

#Id: 8862

#XL - T Zoology

In vertebrates, stabilization of cohesins requires the cohesin-associated factor sororin.

TLS Online TPP Program

#Id: 8864

#XL - T Zoology

Defects of cohesin’s gene expression regulation function are the cause of a group of diseases collectively called cohesinopathies.

TLS Online TPP Program

#Id: 8865

#XL - T Zoology

The phosphorylation state of T14 and Y15 is controlled by a dual-specificity protein kinase known as Wee1 and a pair of dual-specificity phosphatases, Cdc25B and Cdc25C (Threonine 14 is not phosphorylated in S. pombe CDK1)

TLS Online TPP Program

#Id: 8866

#XL - T Zoology

TLS Online TPP Program

#Id: 8867

#XL - T Zoology

Cdc25B is act as a starter phosphatase that initiates CDK1 activation

Cdc25C is the workhorse phosphatase that activates the vast majority of cyclin-CDK1 complexes