The GPK in skeletal muscle is a huge protein with multiple subunits:

Kinase subunit contains the catalytic activity that activates GP 

Regulatory subunits is the ubiquitous protein calmodulin

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The UVR8- COP1-SPA complex then activates the transcription of the major transcription factor HY5, which controls the expression of many of the genes induced by UV-B.

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Binding of the ligand to the receptor causes the receptor to change from an inactive conformation (R) to an active conformation (R*). Only the active R* conformation of the receptor can trigger the signal transduction pathway.

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The affinity of a signal molecule’s binding to its receptor is quantified by the dissociation constant for binding (Kd).

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A plot of the amount of ligand bound to the receptor

[RL] versus the amount of free ligand [L] called a

ligand-binding or saturation curve

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The levels of insulin present in the body and the Kd for binding of insulin to its receptor on liver cells,

1.4 × 10−10 M (0.14 nM). The normal concentration of insulin in the blood is  5 × 10−12 M. 

The fraction of insulin receptors with bound insulin, [RL]/[RT], at equilibrium as 0.0344

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The tighter the binding of a ligand to its receptor,the lower the concentration of ligand needed to achieve binding to 50 percent of the receptors.