The resultant efflux of NaCl triggers massive water loss through the intestine as cells respond to the ensuing osmotic imbalance causes severe dehydration and electrolyte loss.

TLS Online TPP Program

#Id: 7885

#XL - Q Biochemistry

VDAC 

A multifunctional transmembrane channel protein (similar in structure to bacterial porins) allow passing of  ions and most small hydrophilic molecules (up to about 5000 Da).

TLS Online TPP Program

#Id: 7884

#XL - Q Biochemistry

The most abundant protein in the outer mitochondrial membrane is a mitochondrial β-barrel porin called VDAC (voltage-dependent anion channel).

TLS Online TPP Program

#Id: 7883

#XL - Q Biochemistry

MICOS function as a diffusion barrier to prevent mixing of the distinct proteins and lipids in the boundary membrane and crista membranes.

TLS Online TPP Program

#Id: 7882

#XL - Q Biochemistry

The binding partners for MICOS in the outer membrane are Tom and SAM protein complexes, (involved in import of proteins into the mitochondria). 

TLS Online TPP Program

#Id: 7881

#XL - Q Biochemistry

MICOS mediates close juxtaposition of the outer membrane and inner membrane by binding to outer membrane–associated proteins

TLS Online TPP Program

#Id: 7880

#XL - Q Biochemistry

MICOS has an integral membrane protein subunit that homo-oligomerizes and bends the inner membrane to produce high curvature.