Negative regulators of TGF-β signaling are induced by TGF-β signaling (Example of Negative feedback): 

Ski 

SnoN 

I-Smads (Smad7)

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Outside-in signaling

Binding of integrins to their ligands induces conformational changes in their cytoplasmic domains, directly or indirectly altering their interactions with cytoplasmic proteins

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Inside-out signaling

intracellular signaling pathways can, via adapter proteins, modify the ability of integrins to bind

to their extracellular ligands

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Integrin exist in two conformations: 

Inactive, low-affinity, “bent” conformation  

Active, high-affinity, “extended” conformation

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Activation of integrins involves:

Conformational changes near the propeller and 

 βA domains

Separation of the transmembrane and cytoplasmic domains

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Hemidesmosomes are integrin-containing anchoring junctions that attach cells to elements of the underlying extracellular matrix.

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Integrins have an important function in neuroregeneration after injury of the peripheral nervous system.