Monomeric Ras protein 

(∼170 amino acids) belongs to the GTPase superfamily of

intracellular switch proteins

TLS Online TPP Program

#Id: 10028

#XL - T Zoology

In certain immune cells, NF-κB stimulates expression of iNOS (inducible isoform of the enzyme that produces NO), which is toxic to bacterial cells

TLS Online TPP Program

#Id: 10029

#XL - T Zoology

In resting cells,

NF-κB binds directly to an inhibitor called I-κBα

TLS Online TPP Program

#Id: 10030

#XL - T Zoology

A single molecule of I-κBα binds to N-terminal domains of the p50–p65 subunits, masking their NLS.

TLS Online TPP Program

#Id: 10031

#XL - T Zoology

I-κB kinase 

three-protein complex and is responsible for releasing NF-κB from sequestration

TLS Online TPP Program

#Id: 10032

#XL - T Zoology

Within minutes of stimulation of the cell, β subunit of

I-κB kinase becomes activated by phosphorylation

TLS Online TPP Program

#Id: 10033

#XL - T Zoology

β subunit of I-κB kinase phosphorylates two N-terminal serine residues on I-κBα