PDK1 can phosphorylate PKB on a critical threonine residue in its activation loop

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Close inbreeding is harmful because it increases the proportion of homozygotes and thereby boosts the probability that deleterious and lethal recessive alleles.

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A recessive allele (a) that causes a genetic disease has a frequency (q) of 0.01. If the population mates randomly (F = 0), the frequency of individuals affected by the disease (aa) will be q = 0.01 = 0.0001.

However, if F = 0.25 expected frequency of the aa is .0026.

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Effects of inbreeding on Japanese children

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Negative assortative mating refers to a tendency for unlike individuals to mate. people engaged in negative assortative mating for height.

Increases the frequency of heterozygous genotypes (Aa).

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Mutation

Mutation has changed the allelic frequency.

it increases genetic variation within populations and between population.