GTP-bound Cdc42, binds to and activates the Ste20 kinase.

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Negative feedback regulation by MAP Kinase

activated MAP kinase triggers an increase in the expression of dual-specificity phosphatases (DUSPs), particularly DUSP6.

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Hormonal stimulation of GPCR leads to the activation of PLC (IP3/DAG pathway).

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GPCRs specifically activate the β isoform of PLC (PLCβ)

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Many RTKs and cytokine receptors specifically activate the γ isoform (PLCγ), which contains an SH2 domain.

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Activated RTKs and cytokine receptors promote PLCγ activity in two ways: 

By localizing PLCγ to the membrane

By phosphorylating PLCγ

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The SH2 domains of PLCγ bind to specific phosphotyrosines on the activated RTKs and cytokine receptors, thus positioning PLCγ close to PIP2.