Rho GTPases are the “master builders” of the cell because they can activate an array of kinases and cytoskeletal binding proteins that remodel cytoskeletal elements to alter cell shape and movement

TLS Online TPP Program

#Id: 8860

#XL - T Zoology

During S phase

DNA-bound G1 cohesins Convert into cohesive complexes by cohesin acetyl transferases (CoATs)

which acetylate Smc3 subunit & prevents unloading of cohesins by Pds5-Wapl, thereby stabilizing the cohesins on chromosomes.

TLS Online TPP Program

#Id: 8862

#XL - T Zoology

In vertebrates, stabilization of cohesins requires the cohesin-associated factor sororin.

TLS Online TPP Program

#Id: 8864

#XL - T Zoology

Defects of cohesin’s gene expression regulation function are the cause of a group of diseases collectively called cohesinopathies.

TLS Online TPP Program

#Id: 8865

#XL - T Zoology

The phosphorylation state of T14 and Y15 is controlled by a dual-specificity protein kinase known as Wee1 and a pair of dual-specificity phosphatases, Cdc25B and Cdc25C (Threonine 14 is not phosphorylated in S. pombe CDK1)

TLS Online TPP Program

#Id: 8866

#XL - T Zoology

TLS Online TPP Program

#Id: 8867

#XL - T Zoology

Cdc25B is act as a starter phosphatase that initiates CDK1 activation

Cdc25C is the workhorse phosphatase that activates the vast majority of cyclin-CDK1 complexes