Following statements are regarding to Shivering, which is the most potent mechanism for increasing heat production in the body. 

A. Cold environmental temperatures activate centers in the posterior hypothalamus during shivering, which then activate the α and γ motoneurons innervating skeletal muscle. 

B. Shivering involves skeletal muscle contracts rhythmically, generating heat and raising body temperature.

C. Shivering involves stimulation of Na+-K+ ATPase and raising body temperature.

D. Shivering involves stimulation of β receptors in brown fat, which increases metabolic rate and heat production.

Which of the following combination is correct?

#Question id: 896

#Unit 1. Molecules and their Interaction Relevant to Biology

van’t Hoff plot is drawn between

#Question id: 895

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following is van’t Hoff plot equation?

#Question id: 894

#Unit 1. Molecules and their Interaction Relevant to Biology

When stress conditions arise, or when protein synthesis threatens to overwhelm the protein-folding capacity of the ER, unfolded proteins can accumulate. These conditions trigger the unfolded protein response (UPR)

a) unfolded protein response ensures to reduces the rate of protein synthesis by mTOR pathway

b) Amyloid aggregates that form before the UPR can come into play may be removed. Some are degraded by autophagy

c) Amyloid aggregates that can be removed by other mechanism such as lysosomal degradations

d)  UPR also bring the various systems into alignment by increasing the concentration of chaperones in the oxygen deprived conditions

Which of the following statements would be incorrect?

#Question id: 893

#Unit 1. Molecules and their Interaction Relevant to Biology

Like E.coli eukaryotic cells also contain chaperonin, which of the following in eukaryotic chapronin is incorrect?

#Question id: 892

#Unit 1. Molecules and their Interaction Relevant to Biology

Assisted protein folding is mediated by a group of proteins known as chaperons, which of the following statements is incorrectly reperesents chaperon activity;

#Question id: 891

#Unit 1. Molecules and their Interaction Relevant to Biology

The folding pathways of some proteins require two enzymes that catalyze isomerization reactions such as,

a) Peptide prolyl isomerase (PPI)  catalyzes the elimination of folding intermediates with inappropriate disulfide cross-links

b) Protein disulfide isomerase (PDI) enzyme that catalyzes the interchange, or shuffling, of disulfide bonds until the bonds of the native conformation are formed

c) Peptide prolyl cis-trans isomerase (PPI) catalyzes the interconversion of the cis and trans isomers of Proline residue peptide bonds

d) Peptide prolyl isomerase (PPI) can be a fast step in the folding of proteins that contain some Pro peptide bonds in the cis conformation

Which of the following combinations is correct about protein folding pathways?