MAC is the binding and polymerization of C9 to the C5b678 complex, completed MAC, which has a tubular form and functional pore diameter of 70 Å to 100 Å.

TLS Online TPP Program

#Id: 10559

#Unit 4. Cell Communication and Cell Signaling

In cells lacking functional caspase-8 or FADD, TNFα

triggers an alternative pathway, necroptosis.

TLS Online TPP Program

#Id: 10560

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10561

#Unit 4. Cell Communication and Cell Signaling

Necroptosis pathway triggered by activation of RIPK1 kinase.

TLS Online TPP Program

#Id: 10562

#Unit 4. Cell Communication and Cell Signaling

Activated RIPK1 forms multiprotein complexes via its RHIM domain with the kinase RIPK3, and RIPK3 becomes activated by phosphorylation

TLS Online TPP Program

#Id: 10563

#Unit 4. Cell Communication and Cell Signaling

Active RIPK3 phosphorylates the kinase-like domain of the MLKL protein

TLS Online TPP Program

#Id: 10564

#Unit 4. Cell Communication and Cell Signaling

Phosphorylated MLKL form

oligomers that insert into the plasma membrane and form holes, allowing Ca2+ entry.