During human chromosome rearrangements deletion onto the chromosome 5 in the short arm causes Cri-du-chat syndrome.

TLS Online TPP Program

#Id: 1554

#Unit 2. Cellular Organization

The dyneins are a family of minus end–directed microtubule motors.

TLS Online TPP Program

#Id: 7769

#Unit 2. Cellular Organization

Nuclear envelope

Double-membrane structure; the outer membrane is continuous with the endoplasmic reticulum and the two membranes are perforated by nuclear pore complexes

TLS Online TPP Program

#Id: 7770

#Unit 2. Cellular Organization

The inner nuclear membrane contains proteins that act as binding sites for chromosomes and for the nuclear lamina.

TLS Online TPP Program

#Id: 7771

#Unit 2. Cellular Organization

Nuclear lamina

Fibrous network on the inner surface of the nuclear envelope composed of lamin intermediate filaments that provides structural support for the nuclear envelope and also acts as an anchoring site for chromosomes.

TLS Online TPP Program

#Id: 7772

#Unit 2. Cellular Organization

The inner membrane is surrounded by the outer nuclear membrane, which is continuous with the membrane of the ER. The outer nuclear membrane is studded with ribosomes engaged in protein synthesis.

TLS Online TPP Program

#Id: 7773

#Unit 2. Cellular Organization

Transport of proteins from the cytoplasm into the nucleus and movement of macromolecules, including mRNAs, tRNAs, and ribosomal subunits, out of the nucleus occurs through nuclear pores, which span both membranes of the nuclear envelope.