Wolf–Hirschhorn syndrome- Deletion on 4, short arm

TLS Online TPP Program

#Id: 7068

#Unit 3. Fundamental Processes

Class I enzymes attach the amino acid to the 2’-OH of the tRNA and are generally monomeric. Class II enzymes attach the amino acid to the 3’-OH of the tRNA and are typically dimeric or tetrameric.The amino acids for which the Class I synthetases are specific tend to be larger and more hydrophobic than those for Class II synthetases.

TLS Online TPP Program

#Id: 7069

#Unit 3. Fundamental Processes

TLS Online TPP Program

#Id: 7070

#Unit 3. Fundamental Processes

TLS Online TPP Program

#Id: 7071

#Unit 3. Fundamental Processes

TLS Online TPP Program

#Id: 7072

#Unit 3. Fundamental Processes

The charging of a tRNA with its cognate amino acid is a remarkably accurate process.

Experimental measurements indicate, for example, that at equal concentrations of isoleucine and valine, IleRS transfers ∼40,000 isoleucines to tRNAIle for every valine it so transfers.

TLS Online TPP Program

#Id: 7073

#Unit 3. Fundamental Processes

This rejection of noncognate tRNAs at a stage of the reaction that precedes the synthesis of misacylated tRNA is sometimes referred to as kinetic proofreading.