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TLS Online TPP Program

#Id: 2280

The carboxy-terminal domain of the a subunit (aCTD) recognizes the Up-element (where present), whereas s regions 2 and 4 recognize the –10 and –35 regions


#Unit 3. Fundamental Processes #Eukaryotic transcription factors and machinery #Part B Pointers
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TLS Online TPP Program

#Id: 382

#Unit 2. Cellular Organization

H3 and H4 histones first form heterodimers that then come together to form a tetramer with two molecules each of H3 and H4. While H2A and H2B form heterodimers in solution but not tetramers. This assembly without DNA called Histone-only Intermediates 
TLS Online TPP Program

#Id: 383

#Unit 2. Cellular Organization

First the H3.H4 assemble into tetramer (HOI) then DNA wrapped over H3.H4 tetramer. 
TLS Online TPP Program

#Id: 384

#Unit 2. Cellular Organization
TLS Online TPP Program

#Id: 385

#Unit 2. Cellular Organization

H32-H42 tetramer accounts for the diameter of the octamer and H32-H42 tetramer alone can organize DNA in vitro into particles that display the properties of the core particle.
 
TLS Online TPP Program

#Id: 386

#Unit 2. Cellular Organization

The H32.H42 tetramer bound to DNA recruits two copies of the H2A.H2B dimer to complete the assembly of the final nucleosome
TLS Online TPP Program

#Id: 387

#Unit 2. Cellular Organization

The nucleosome has an approximate twofold axis of symmetry, called the dyad axis.