In DMS footprinting, Unmethylated (or hypermethylated) sites show up on electrophoresis and demonstrate where the protein is bound to the DNA. 

TLS Online TPP Program

#Id: 5425

#Unit 7. System Physiology – Animal

In the peripheral nervous system, myelin is compacted when the extracellular portions of a membrane protein called protein zero (P0 ) lock to the extracellular portions of P0 in the apposing membrane

TLS Online TPP Program

#Id: 5426

#Unit 7. System Physiology – Animal

In the CNS of mammals, most neurons are myelinated, but the cells that form the myelin are oligodendrocytes rather than Schwann cells

TLS Online TPP Program

#Id: 5427

#Unit 7. System Physiology – Animal

In multiple sclerosis, a crippling autoimmune disease, patchy destruction of myelin occurs in the CNS

TLS Online TPP Program

#Id: 5428

#Unit 7. System Physiology – Animal

Orthograde transport

moves from the cell body toward the axon terminals 

occurs along microtubules that run along the length of the axon and requires dynein and kinesin

TLS Online TPP Program

#Id: 5429

#Unit 7. System Physiology – Animal

Orthograde transport has:

Fast axonal transport occurs at about 400 mm/day 

Slow axonal transport occurs at 0.5 to 10 mm/day

TLS Online TPP Program

#Id: 5430

#Unit 7. System Physiology – Animal

Retrograde transport, is in the opposite direction (from the nerve ending to the cell body), occurs along microtubules at about 200 mm/day.