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TLS Online TPP Program

#Id: 3306

Unlike base excision repair, the nucleotide excision repair enzymes do not recognize any particular lesion. Rather, this system works by recognizing distortions to the shape of the double helix, such as those
caused by a thymine dimer or by the presence of a bulky chemical adduct on a base.

#Unit 3. Fundamental Processes #DNA damage and repair mechanisms #Part B Pointers
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TLS Online TPP Program

#Id: 355

#Unit 1. Structure and Function of Biomolecules

Acetyl-CoA inhibits the transacetylase component whereas NADH inhibits the dihydrolipoyl dehydrogenase component. 
TLS Online TPP Program

#Id: 356

#Unit 1. Structure and Function of Biomolecules

The reaction catalyzed by citrate synthase is essentially a Claisen condensation, involving a thioester (acetyl-CoA) and a ketone (oxaloacetate)
TLS Online TPP Program

#Id: 359

#Unit 1. Structure and Function of Biomolecules

Eukaryotic cells have two isozymes of aconitase
• The mitochondrial isozyme (convert citrate to isocitrate in the citric acid cycle)
• The cytosolic isozyme 
TLS Online TPP Program

#Id: 360

#Unit 1. Structure and Function of Biomolecules

The cytosolic isozymes has two distinct function, It catalyzes the conversion of citrate to isocitrate, providing the substrate for a cytosolic isocitrate dehydrogenase that generates NADPH as reducing power for fatty acid synthesis and other anabolic processes in the cytosol. It also has a role in cellular iron homeostasis
TLS Online TPP Program

#Id: 363

#Unit 1. Structure and Function of Biomolecules

When cellular iron concentrations return to normal levels, IRP1 is converted to aconitase, and IRP2 undergoes proteolytic degradation, ending the low-iron response.
TLS Online TPP Program

#Id: 364

#Unit 1. Structure and Function of Biomolecules

Pyruvate kinase acts in the nucleus to regulate the transcription of genes that respond to thyroid hormone. Glyceraldehyde 3-phosphate dehydrogenase moonlights both as uracil DNA glycosylase, effecting the repair of damaged DNA, and as a regulator of histone H2B transcription.