Camptothecin is an inhibitor of eukaryotic type I topoisomerases.

Irinotecan (Campto) and topotecan (Hycamtin)—used to treat colorectal cancer and ovarian cancer.

All these drug's act by trapping the topoisomerase-DNA complex in which the DNA is cleaved, inhibiting religation.

TLS Online TPP Program

#Id: 3351

#Unit 6. System Physiology – Plant

The streaming of protons through the F_o pore causes the cylinder of c subunits and the attached ϒ subunit to rotate about the long axis of ϒ, passes through the center of the α₃β₃ spheroid

TLS Online TPP Program

#Id: 10033

#Unit 4. Cell Communication and Cell Signaling

β subunit of I-κB kinase phosphorylates two N-terminal serine residues on I-κBα

TLS Online TPP Program

#Id: 8920

#Unit 2. Cellular Organization

During anaphase, when cyclin B-CDK1 activity is extinguished but Aurora and Polo kinases are still active, Aurora B phosphorylates MKLP1 and displaces the 14-3-3, allowing compact the spindle midzone.

TLS Online TPP Program

#Id: 4827

#Unit 13. Methods in Biology

The formula for the null hypothesis is H₀ : p = p₀

TLS Online TPP Program

#Id: 5918

#Unit 3. Fundamental Processes

The holoenzyme assembles on replication fork DNA in three stages:

1. First the clamp loader uses hydrolysis of ATP to bind b subunits to a template primer complex.

2. Binding to DNA changes the conformation of the site on b that binds to the clamp loader, and as a result it now has a high affinity for the core polymerase

3. A t dimer binds to the core polymerase, and provides a dimerization function that binds a second core polymerase