A number of amino acids (Asp, Glu, Asn, Gln, Arg and His) have weak electronic transitions at around 210 nm. Usually, these cannot be observed in proteins because

they are masked by the more intense peptide bond absorption.

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#Unit 4. Cell Communication and Cell Signaling

Stages in hematopoiesis

TLS Online TPP Program

#Id: 1904

#Unit 4. Cell Communication and Cell Signaling

B cell properties

1.    They are APCs

2.    They can express MHC2

3.    Have surface marker  CD19

4.    Antibodies at surface of b cell – IgM, IgD

5.    Part of Adaptive immunity

6.    B cell convert into plasma cell

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#Id: 1905

#Unit 4. Cell Communication and Cell Signaling

Surface protein on B cell

CR2(CR21)

CD19

TAPA-1(CD81)

 mIg

Igα/ Igβ

(CD79a and CD79B)

 TLR

CD40

B7 (CD80/86)

ICAM-1

MHC-1 and 2

CD 22

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#Unit 4. Cell Communication and Cell Signaling

Formation of mature B-cell

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#Id: 1907

#Unit 4. Cell Communication and Cell Signaling

Progress through their developmental program

TLS Online TPP Program

#Id: 1908

#Unit 4. Cell Communication and Cell Signaling

B-Cell Development