In human cells, the centromere- specific protein CENP-B is required to initiate modifications of histone H3 (deacetylation of K9 and K14, followed by methylation of K9) that trigger an association with HP1 that leads to the formation of heterochromatin in the region.

TLS Online TPP Program

#Id: 10530

#Unit 4. Cell Communication and Cell Signaling

All members of the Bcl-2 family share a close homology in up to four characteristic regions, termed the Bcl-2 homology domains

TLS Online TPP Program

#Id: 10531

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10532

#Unit 4. Cell Communication and Cell Signaling

Pro-survival members-

Bcl-2, Bcl-xL, Bcl-w, Mcl-1, A1

TLS Online TPP Program

#Id: 10533

#Unit 4. Cell Communication and Cell Signaling

Pro-apoptotic members form channels in the mitochondrial outer membrane

Bax, Bak, Bok

TLS Online TPP Program

#Id: 10534

#Unit 4. Cell Communication and Cell Signaling

BH3-only proteins: Regulate activity of Bcl-2 and Bax/Bak proteins

Bim, Puma, Noxa, Bik, Bmf, Bad, Hrk, Bid

TLS Online TPP Program

#Id: 10535

#Unit 4. Cell Communication and Cell Signaling

Neurotrophins:

NGF 

Brain derived neurotrophic factor 

Neurotrophin-3 (NT-3)