FG-nucleoporins, the central channel of the NPC filled with a fluidlike phase that allows the diffusion of small molecules while excluding unchaperoned hydrophilic proteins larger than 40 kDa.

TLS Online TPP Program

#Id: 6962

#Unit 8. Inheritance Biology

TLS Online TPP Program

#Id: 6963

#Unit 8. Inheritance Biology

It can be identified by G banding chromosome. 

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#Id: 6964

#Unit 8. Inheritance Biology

Philadelphia chromosome

Reciprocal translocation between the long arm of chromosome 22 and the tip of the long arm of chromosome 9. This translocation produces a shortened chromosome 22, called the Philadelphia chromosome.

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#Id: 6965

#Unit 8. Inheritance Biology

At the end of a normal chromosome 9 is a potential cancer-causing gene called c- ABL.   As a result of the translocation, part of the cABL gene is fused with the BCR gene from chromosome 22. The protein produced by this BCR–c-ABL fusion gene is much more active than the protein produced by the normal c- ABL gene.

TLS Online TPP Program

#Id: 6966

#Unit 8. Inheritance Biology

TLS Online TPP Program

#Id: 6967

#Unit 8. Inheritance Biology

Burkitt lymphoma Burkitt lymphoma possess a reciprocal translocation between chromosome 8 and chromosome 2, 14, or 22.  This translocation relocates a gene called c-MYC is next to a gene that encodes an immunoglobulin protein.