A carbon atom with four different substituents is said to be asymmetric, and asymmetric carbons are called chiral centers

Chiral carbon most distant from the carbonyl carbon has the same configuration as the chiral carbon in D-glyceraldehyde.

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#Unit 2. Cellular Organization

Lysine  in the histone tails are the most common targets of modification.

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#Unit 2. Cellular Organization

Acetylation, methylation, ubiquitylation, and sumoylation all occur on the free epsilon amino group of lysine.

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#Unit 2. Cellular Organization

Acetylation neutralizes the positive charge of lysine so disrupts DNA Histone interactions.

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#Unit 2. Cellular Organization

lysine methylation retains the positive charge, and lysine can be mono-, di-, or trimethylated.

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#Unit 2. Cellular Organization

Histone codes are specific and conserved residues that undergoes to modification and changes expression of chromatin.

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#Unit 2. Cellular Organization

Histone tail modifications