The curvature of the crista junctions is due to a protein complex called MICOS (mitochondrial contact site and cristae organizing system).

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#Unit 3. Fundamental Processes

Hence Cdc6 and Cdt1 are the key licensing factors and helicase loading proteins.

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#Unit 3. Fundamental Processes

Cdc6 has an ATPase activity that is required for it to support initiation.

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#Unit 3. Fundamental Processes

The presence of Cdc6 and Cdt1 at the yeast origin allows the MCM proteins to bind to the complex in G1 in the inactive state.

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#Unit 3. Fundamental Processes

Helicases are loaded during G1 are only activated to unwind DNA and initiate replication after cells pass from the G1 to the S phase of the cell cycle in effect with S phase CDKC

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#Unit 3. Fundamental Processes

The origin enters S phase in the condition of a prereplication complex, which contains ORC, Cdc6, Cdt1, and the inactive helicase

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#Unit 3. Fundamental Processes

The MCM2-7 proteins form a six-member ring-shaped complex around DNA. MCM2,3,5 are regulatory, while MCM4,6,7 have the helicase activity.