Lys & Arg have four ionisations zones

1. 1--------pK1 – charge +2

2. pK1---------pK2 charge +1

3. pK2---------pKr charge 0

4. pKr---------14 charge -1

TLS Online TPP Program

#Id: 8886

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8887

#Unit 2. Cellular Organization

The mitotic CDKs phosphorylate specific nucleoporins, which causes nuclear pore complexes to dissociate during prophase. 

TLS Online TPP Program

#Id: 8888

#Unit 2. Cellular Organization

A key function of mitotic CDKs, together with other protein kinases and ubiquitin-protein ligases, is to induce the formation of the mitotic spindle, also known as the mitotic apparatus.

TLS Online TPP Program

#Id: 8889

#Unit 2. Cellular Organization

Centrosomes contain γ tubulin, which forms specific ringlike complexes (γ TuRCs) that, have the ability to nucleate microtubules and form a bipolar spindle

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#Id: 8890

#Unit 2. Cellular Organization

Mitotic spindle attach to chromosomes via specialized protein structures known as kinetochores

TLS Online TPP Program

#Id: 8891

#Unit 2. Cellular Organization

Kinetochores assemble on regions of chromosomal DNA marked by a centromere-specific H3 histone variant called CENP-A.