Pointers

The cytosolic isozymes has two distinct function, It catalyzes the conversion of citrate to isocitrate, providing the substrate for a cytosolic isocitrate dehydrogenase that generates NADPH as reducing power for fatty acid synthesis and other anabolic processes in the cytosol. It also has a role in cellular iron homeostasis

TLS Online TPP Program

#Id: 363

#Unit 1. Structure and Function of Biomolecules

When cellular iron concentrations return to normal levels, IRP1 is converted to aconitase, and IRP2 undergoes proteolytic degradation, ending the low-iron response.

TLS Online TPP Program

#Id: 364

#Unit 1. Structure and Function of Biomolecules

Pyruvate kinase acts in the nucleus to regulate the transcription of genes that respond to thyroid hormone. Glyceraldehyde 3-phosphate dehydrogenase moonlights both as uracil DNA glycosylase, effecting the repair of damaged DNA, and as a regulator of histone H2B transcription.

TLS Online TPP Program

#Id: 366

#Unit 1. Structure and Function of Biomolecules

The enzyme that catalyzes this reversible reaction is called succinyl-CoA synthetase or succinic thiokinase

Pointers

The trans form is the more favoured state because in this arrangement repulsion between non-bonded atoms connected to the Cα centre are minimized. For most peptide bonds the ratio of cis to trans configurations is approximately 1:1000.

The trans form is the more favoured state because in this arrangement repulsion between non-bonded atoms connected to the Cα centre are minimized.
For most peptide bonds the ratio of cis to trans configurations is approximately 1:1000.