Protein stability is the net balance of forces, which determine whether a protein will be in its native folded conformation or a denatured state.

#Id: 7905

#Unit 2. Cellular Organization

Mitophagy provides Mitochondrial Quality Control

#Id: 7906

#Unit 2. Cellular Organization

#Id: 7907

#Unit 2. Cellular Organization

Parkinson’s disease is caused by mutations in two gene encoding proteins that can mediate mitophagy:

PINK1 (a kinase)

Parkin (E3 ubiquitin ligase)

#Id: 7908

#Unit 2. Cellular Organization

In healthy mitochondria, PINK1 resides in the mitochondrial matrix.

In damaged or dysfunctional mitochondria, PINK1 resides on the outer mitochondrial membrane, where it recruits cytosolic Parkin.

#Id: 7909

#Unit 2. Cellular Organization

#Id: 7910

#Unit 2. Cellular Organization

Mitochondria-associated membranes (MAMs)

The portions of the ER membranes that form special contact regions with the mitochondria.