Cdc25B is act as a starter phosphatase that initiates CDK1 activation

Cdc25C is the workhorse phosphatase that activates the vast majority of cyclin-CDK1 complexes

TLS Online TPP Program

#Id: 686

#Unit 3. Fundamental Processes

 Shelterin proteins bound at the telomere distinguish telomeres from other DNA ends in the cell prevents telomeres from normal DSBR

TLS Online TPP Program

#Id: 687

#Unit 3. Fundamental Processes

Elimination of Shelterin leads to the recognition of the telomeres as normal DNA breaks.

TLS Online TPP Program

#Id: 688

#Unit 3. Fundamental Processes

Telomeres form a looped structure in the cell called as t-loop

TLS Online TPP Program

#Id: 689

#Unit 3. Fundamental Processes

TLS Online TPP Program

#Id: 690

#Unit 3. Fundamental Processes

t-loop is formed by the 3’-ssDNA end of the telomere invading the dsDNA region of the telomere

TLS Online TPP Program

#Id: 691

#Unit 3. Fundamental Processes

TRF2 is capable of directing t-loop formation with purified telomere DNA.